Biodegradability and tissue reaction of random copolymers ofL-leucine,L-aspartic acid, andL-aspartic acid esters
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منابع مشابه
Biodegradability and tissue reaction of random copolymers of L-leucine, L-aspartic acid, and L-aspartic acid esters.
A series of copoly(alpha-amino acids) with varying percentages of hydrophilic (L-aspartic acid) and hydrophobic monomers (L-leucine, beta-methyl-L-aspartate, and beta-benzyl-L-aspartate) were implanted subcutaneously in rats and the macroscopic degradation behavior was studied. Three groups of materials (A,B,C) with different ranges of hydrophilicity were distinguished: A) hydrophobic materials...
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A series of copolymers of L-leucine and/3-benzyI-L-aspartate [Leu/Asp(OBz)] covering the range 30-70 mol % of L-leucine, was synthesized by the N-carboxyanhydride (NCA) method. The copolymers were characterized by elemental analysis, infra-red spectroscopy and viscometry. For all compositions high molecular weight copolymers were prepared with excellent film-forming properties. Tercopolymers of...
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Aspartic acid, like glutamic acid, occupies a central position in amino acid metabolism. In most tissues it takes part in the transamination reaction (1). In the liver and the kidney, where all amino acids undergo cleamination, the rate of this process for aspartic acid is second only to glutamic acid (2). For these reasons, one would expect the exchange of amino nitrogen of aspartic acid with ...
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No one of the methods proposed for the synthesis of aspartic acid is entirely satisfactory as a practical procedure. The synthesis, described in a recent paper (1) from this laboratory, has been utilized in preparing 50 to 60 gm. lots of recrystallized aspartic acid but even here the beginning reagents are expensive, the over-all yield is only about 30 per cent of the theoretical, and the proce...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research
سال: 1977
ISSN: 0021-9304,1097-4636
DOI: 10.1002/jbm.820110308